Retrospective study of the relative frequency of feline hepatobiliary disease in New Zealand based on 10years of hepatic biopsy samples.
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Other Title
Authors
Fluen, T.
Hardcastle, M.
Smith, H. L.
Gear, Robyn
Hardcastle, M.
Smith, H. L.
Gear, Robyn
Author ORCID Profiles (clickable)
Degree
Grantor
Date
2019-09-23
Supervisors
Type
Journal Article
Ngā Upoko Tukutuku (Māori subject headings)
Keyword
New Zealand
cats (Felis catus)
hepatobiliary diseases
liver diseases
hepatic lipidosis
diagnosis
incidence
histopathology
cats (Felis catus)
hepatobiliary diseases
liver diseases
hepatic lipidosis
diagnosis
incidence
histopathology
ANZSRC Field of Research Code (2020)
Citation
Fluen, T., Hardcastle, M., Smith, H. L., & Gear, R .N. A. (2019). Retrospective study of the relative frequency of feline hepatobiliary disease in New Zealand based on 10 years of hepatic biopsy samples. Veterinary Record Open, 6:e000367, 1-8. doi:doi:10.1136/vetreco-2019-000367
Abstract
AIMS
To retrospectively determine the relative frequency of feline hepatobiliary diseases from biopsy specimens submitted to a single laboratory across a 10-year period and to establish whether age, sex or breed associations exist.
METHODS
Histopathological data from 154 liver biopsies of New Zealand cats sampled between 2008 and 2018 were analysed. The samples were allocated to primary, secondary and tertiary disease categories using criteria established by the World Small Animal Veterinary Association. Breed associations were derived using ORs and 95% CIs. Gender and age associations were also evaluated.
RESULTS
The most frequently diagnosed hepatobiliary diseases were lymphocytic cholangitis (20 per cent), hepatitis (16.9 per cent), reversible hepatocellular injury (16.4 per cent), neutrophilic cholangitis (9.7 per cent), haematopoietic neoplasia (9.7 per cent), hepatocellular neoplasia (5.6 per cent) and cholangiocellular neoplasia (4.1 per cent). Burmese cats were found to be at significantly increased risk of both biliary and parenchymal diseases and Birman cats to be at significantly increased risk of parenchymal disease. Domestic longhair cats were at significantly increased risk of hepatobiliary neoplasia. Birman cats were at significantly increased risk of hepatitis while domestic shorthair cats were at significantly decreased risk of neutrophilic cholangitis, reversible hepatocellular injury and hepatitis.
CONCLUSIONS
This study is the first retrospective examination of the relative frequency of hepatobiliary disease in biopsy specimens from New Zealand cats. Some breeds were associated with specific histopathology
Publisher
British Veterinary Association (BVA)
Permanent link
Link to ePress publication
DOI
doi:10.1136/vetreco-2019-000367
Copyright holder
© British Veterinary Association 2019.
Copyright notice
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, an indication of whether changes were made, and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/.