Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC)
Loading...
Supplementary material
Other Title
Authors
Wong, Chih M.
Hawkins, Nathaniel M.
Petrie, Mark C.
Jhund, Pardeep S.
Gardner, Roy S.
Ariti, Cono A.
Poppe, K.K.
Earle, Nikki
Whalley, Gillian
Squire, I.B.
Doughty, Robert N.
McMurray, John J.V.
Hawkins, Nathaniel M.
Petrie, Mark C.
Jhund, Pardeep S.
Gardner, Roy S.
Ariti, Cono A.
Poppe, K.K.
Earle, Nikki
Whalley, Gillian
Squire, I.B.
Doughty, Robert N.
McMurray, John J.V.
Author ORCID Profiles (clickable)
Degree
Grantor
Date
2014-06-17
Supervisors
Type
Journal Article
Ngā Upoko Tukutuku (Māori subject headings)
Keyword
heat failure
younger paitients
meta-analysis
younger paitients
meta-analysis
ANZSRC Field of Research Code (2020)
Citation
Wong, C.M., Hawkins, N.M., Petrie, M.C., Jhund, P.S., Gardner, R.S., Ariti, C.A., Poppe, K.K., Earle, N., Whalley, G.A., Squire, I.B., Doughty, R.N., McMurray, J.J.V., and on behalf of the MAGGIC Investigators. (2014). Heart failure in younger patients: the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC). European Heart Journal, 35, pp.2714-2721. NOTE: Available from link below.
Abstract
Aim
Our understanding of heart failure in younger patients is limited. The Meta-analysis Global Group inChronic Heart Failure (MAGGIC) database, which consisted of 24 prospective observational studies and 7 randomized trials, was used to investigate the clinical characteristics, treatment, and outcomes of younger patients.
Methods and Results
Patients were stratified into six age categories: ,40 (n ¼ 876), 40 – 49 (n ¼ 2638), 50 – 59 (n ¼ 6894), 60 – 69 (n ¼ 12 071), 70 – 79 (n ¼ 13 368), and ≥80 years (n ¼ 6079). Of 41 926 patients, 2.1, 8.4, and 24.8% were younger than 40, 50, and 60 years of age, respectively. Comparing young (,40 years) against elderly (≥80 years), younger patients were more likely to be male (71 vs. 48%) and have idiopathic cardiomyopathy (63 vs. 7%). Younger patients reported better New York Heart Association functional class despite more severe left ventricular dysfunction (median ejection fraction: 31 vs. 42%, all P , 0.0001). Comorbidities such as hypertension, myocardial infarction, and atrial fibrillation were much less common in the young. Younger patients received more disease-modifying pharmacological therapy than their older counterparts. Across the younger age groups (,40, 40 – 49, and 50 – 59 years), mortality rates were low: 1 year 6.7, 6.6, and 7.5%, respectively; 2 year 11.7, 11.5, 13.0%; and 3 years 16.5, 16.2, 18.2%. Furthermore, 1-, 2-, and 3-year mortality rates increased sharply beyond 60 years and were greatest in the elderly (≥80 years): 28.2, 44.5, and 57.2%, respectively.
Conclusion
Younger patients with heart failure have different clinical characteristics including different aetiologies, more severe left ventricular dysfunction, and less severe symptoms. Three-year mortality rates are lower for all age groups under 60 years compared with older patients.
Publisher
Oxford University Press on behalf of European Society of Cardiology
Permanent link
Link to ePress publication
DOI
doi:10.1093/eurheartj/ehu216
Copyright holder
Oxford University Press and the authors
Copyright notice
All rights reserved