Fluralaner and its potential threat to native invertebrates
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Authors
McMenamin, Chloe
Goodwin, Ben
Doyle, Erin
Eason, C.
Cameron, Kristie
Goodwin, Ben
Doyle, Erin
Eason, C.
Cameron, Kristie
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Date
2025
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Conference Contribution - Poster Presentation
Ngā Upoko Tukutuku (Māori subject headings)
Keyword
New Zealand
Aotearoa
crickets (Teleogryllus commodus)
wētā (Hemiandrous spp)
fluralaner
topical treatments
conservation
companion animals
Aotearoa
crickets (Teleogryllus commodus)
wētā (Hemiandrous spp)
fluralaner
topical treatments
conservation
companion animals
ANZSRC Field of Research Code (2020)
Citation
McMenamin, C.M., Goodwin, B.G., Doyle, E., Eason, C., & Cameron, K. (2025, November, 6). Fluralaner and its potential threat to native invertebrates [Poster presentation]. School of Environmental and Animal Sciences Research Symposium 2025, Auckland, New Zealand.
https://hdl.handle.net/10652/7037
Abstract
Fluralaner is a broad-spectrum isoxazoline insecticide and acaricide approved for use in poultry and companion animals in Aotearoa New Zealand due to its efficacy and favourable safety profile in mammals. However, its high environmental persistence and potential toxicity to non target invertebrates raise ecological concerns. Particularly given limited data on its ecotoxicology and environmental fate. This study analysed and reported on the toxicity of fluralaner in Teleogryllus commodus (field crickets) following exposure. Field crickets were selected as a model for native invertebrates that fill similar ecological and behavioral niches. Behavioural observations (e.g., involuntary leg movement without body movement, inability to right themselves, or hyperextended legs while upright) and lethality (no movement after air puffing and probing) were recorded over 72 hour time frame revealed a time-dependent increase in toxicity, with the concentration to cause 50% of test individuals to perish (LC₅₀) values declining from 15.92 mg/ml at 48 hours to 11.67 mg/ml at 72 hours, indicating delayed or cumulative effects. A clear concentration-effect relationship observed, with affect rates rising from 66.7% at 2 mg/ml at 24 hours to 100% at ≥8 mg/ml at 72 hours. These findings underscore the need for more comprehensive environmental risk assessments and consideration for the pharmacokinetic (absorption, distribution, metabolism, and excretion) in the approval process of veterinary compounds like fluralaner.
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