Sleep abnormalities as potential early diagnostic biomarkers for Alzheimer’s disease: A scoping review examining the extent of empirical evidence
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Authors
Baxter, Lucas
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Degree
Master of Osteopathy
Grantor
Unitec, Te Pūkenga - New Zealand Institute of Skills and Technology
Date
2023
Supervisors
Aminian, Saeideh
Friedlander, Tim
Friedlander, Tim
Type
Masters Thesis
Ngā Upoko Tukutuku (Māori subject headings)
Keyword
Alzheimer's disease.
diagnosis
biomarkers
sleep quality
osteopathic medicine
scoping reviews
diagnosis
biomarkers
sleep quality
osteopathic medicine
scoping reviews
ANZSRC Field of Research Code (2020)
Citation
Baxter, L. (2023). Sleep abnormalities as potential early diagnostic biomarkers for Alzheimer’s disease: A scoping review examining the extent of empirical evidence (An unpublished document submitted in partial fulfilment of the requirements for the degree of Masters of Osteopathy) Unitec, Te Pūkenga - New Zealand Institute of Skills and Technology https://hdl.handle.net/10652/6295
Abstract
Alzheimer’s disease is the most common type of dementia, and its prevalence is increasing world-wide. This disease incurs a wide range of complications for individuals and society. No current therapies exist to cure or stop the progression of the disease once diagnosed within an individual. Many risk factors for Alzheimer’s disease are known, although one which has recently emerged within the scientific literature is sleep disturbance. The true implications of the research are at present, incomplete, yet the studies available have shown promise of the potential diagnostic and therapeutic value of sleep. Therefore, this study aimed to examine the extent and nature of research available discussing the role of sleep in Alzheimer’s disease development, as well as the potential utility of specific sleep disturbances to be diagnostic biomarkers for Alzheimer’s disease. A five-stage scoping review framework developed by Arksey and O’Malley was utilised to ensure an in-depth review of the relevant literature was achieved.
From a total of 2,821 studies, 199 were included into this scoping review and classified into four primary themes: 1) Mechanistic links between sleep disturbance and Alzheimer’s disease, 2) Sleep disturbance as a biomarker for Alzheimer’s disease, 3) Sleep as a therapeutic target for Alzheimer’s disease, and 4) Preclinical Alzheimer’s disease definition. This review has covered a range of studies that discussed links between sleep disturbance and Alzheimer’s disease pathogenesis. The findings suggests that certain sleep patterns may have diagnostic and therapeutic uses in Alzheimer’s disease; however, further experimental research is indicated to substantiate these hypotheses. The term preclinical Alzheimer’s disease requires a relevant and concise consensus regarding its definition in order for the aforementioned hypotheses to fully be explored for their respective potential
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