A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study
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Authors
Whalley, Gillian
Author ORCID Profiles (clickable)
Degree
Grantor
Date
2014-11-18
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Type
Journal Article
Ngā Upoko Tukutuku (Māori subject headings)
Keyword
echocardiography
reference ranges
meta-analysis
reference ranges
meta-analysis
ANZSRC Field of Research Code (2020)
Citation
The Echocardiographic Normal Ranges Meta-Analysis of the Left heart EchoNoRMAL)Collaboration.
(2013). A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study. European Heart Journal – Cardiovascular Imaging (2014) 15, 341–348. doi:10.1093/ehjci/jet240 NOTE: Available from link below.
Abstract
Aim To develop age-, sex-, and ethnic-appropriate normative reference ranges for standard echocardiographic measurements of the left heart by combining echocardiographic measurements obtained from adult volunteers without clinical cardiovascular disease or significant cardiovascular risk factors, from multiple studies around the world.
Methods and results The Echocardiographic Normal Ranges Meta-Analysis of the Left heart (EchoNoRMAL) collaboration was established and population-based data sets of echocardiographic measurements combined to perform an individual person data meta-analysis. Data from 43 studies were received, representing 51 222 subjects, of which 22 404 adults aged 18–80 years were without clinical cardiovascular or renal disease, hypertension or diabetes. Quantile regression or an appropriate parametric regression method will be used to derive reference values at the 5th and 95th centile of each measurement against age.
Conclusion This unique data set represents a large, multi-ethnic cohort of subjects resident in a wide range of countries. The resultant reference ranges will have wide applicability for normative data based on age, sex, and ethnicity.
Publisher
Oxford University Press on behalf of the European Society of Cardiology
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Link to ePress publication
DOI
http://dx.doi.org/10.1093/ehjci/jet240
Copyright holder
Oxford University Press
Copyright notice
. All rights reserved. © The Author 2013.