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dc.contributor.authorStehlin, Ellyce
dc.contributor.authorMalpas, Simon C.
dc.contributor.authorBudgett, David M.
dc.contributor.authorBarrett, Carolyn J.
dc.contributor.authorMcCormick, Daniel
dc.contributor.authorWhalley, Gillian
dc.contributor.authorFu, Fumin
dc.contributor.authorBeil, Michael
dc.contributor.authorRigel, Dean F.
dc.contributor.authorGuild, Sarah-Jane
dc.description.abstractMeasurements of left ventricular pressure (LVP) in conscious freely moving animals are uncommon yet could offer considerable opportunity for understanding cardiovascular disease progression and treatment. The aim of this study was to develop surgical methods and validate the measurements of a new high-fidelity solid-state pressure sensor telemetry device for chronically measuring LVP and dP/dt in rats. The pressure sensor catheter tip (2-Fr) was inserted into the left ventricular chamber through the apex of the heart and the telemeter body implanted in the abdomen. Data was measured up to 85 days after implant. The average daytime dP/dt max was 9444 ±363 mmHg/s, ranging from 7870 to 10558 mmHg/s (n=7). A circadian variation in dP/dt max and heart rate (HR) was observed with an average increase during the night phase in dP/dt max of 918 ±84 mmHg/s and in HR of 38 ±3 bpm. The β-adrenergic-agonist isoproterenol, β1-adrenergic agonist dobutamine, Ca2+ channel blocker verapamil and the calcium sensitizer levosimendan were administered throughout the implant period, inducing dose dependent time course changes and absolute changes in dP/dt max of -6000 to +13,000 mmHg/s . The surgical methods and new technologies demonstrated long term stability, sensitivity to circadian variation and the ability to measure large drug induced changes, validating this new solution for chronic measurement of LVP in conscious rats.en_NZ
dc.publisherAmerican Physiological Societyen_NZ
dc.rights8750-7587/13 Copyright © 2013 the American Physiological Societyen_NZ
dc.subjectsolid-state pressureen_NZ
dc.subjectinductive poweren_NZ
dc.titleChronic measurement of left ventricular pressure in freely moving ratsen_NZ
dc.typeJournal Articleen_NZ
dc.rights.holderAmerican Physiological Societyen_NZ
dc.subject.marsden110201 Cardiology (incl. Cardiovascular Diseases)en_NZ
dc.identifier.bibliographicCitationStehlin, E., Malpas, S., Budgett, D., Barrett, C., Mccormick, D., Whalley, G., Fu, F., Bell, M., RIgel, D.F.and Guild, S. (2013). Chronic measurement of left ventricular pressure in freely moving rats. Journal of Applied Physiology (Bethesda, Md. : 1985), 115(11), 1672-82.en_NZ
unitec.institutionUniversity of Aucklanden_NZ
unitec.institutionUnitec Institute of Technologyen_NZ
unitec.institution5Novartis Institutes for BioMedical Research (New Jersey, USA)en_NZ
unitec.publication.titleJournal of Applied Physiologyen_NZ
dc.contributor.affiliationUnitec Institute of Technologyen_NZ
dc.contributor.affiliationUniversity of Aucklanden_NZ
dc.contributor.affiliationNovartis Pharmaceuticals Corporationen_NZ
dc.contributor.affiliationMillar Inc. (Auckland, N.Z.)en_NZ
unitec.institution.studyareaHealth Sciences

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