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dc.contributor.authorWhalley, Gillian
dc.contributor.authorRusinaru, Dan
dc.contributor.authorTribouilloy, Christophe
dc.contributor.authorBerry, Colin
dc.contributor.authorRichards, A.M.
dc.contributor.authorEarle, Nikki
dc.contributor.authorPoppe, K.K.
dc.contributor.authorGuazzi, Marco
dc.contributor.authorMacin, Steller M.
dc.contributor.authorKomajda, Michael
dc.contributor.authorDoughty, Robert N.
dc.date.accessioned2013-05-13T03:27:54Z
dc.date.available2013-05-13T03:27:54Z
dc.date.issued2012
dc.identifier.urihttps://hdl.handle.net/10652/2118
dc.description.abstractHyponatraemia (usually defined as a serum sodium concentration,135 mmol/L)1 is observed in 20% of patients admitted to hospital for heart failure (HF).2 – 4 Studies conducted in various patient populations of chronic and acutely decompensated HF have shown an association between low serum sodium concentration and poor prognosis.2 – 7 Most of these studies were focused on short-term outcomes.2 – 4 Risk models developed in different HF cohorts of outpatients 8,9 and hospitalized patients10212 have suggested that hyponatraemia is one of the most powerful predictors of mortality in HF. Few studies that investigated the relationship between serum sodium concentration and outcome have included patients with heart failure and preserved ejection fraction (HF-PEF).2,9,12 – 14 It is now clear that HF-PEF accounts for a substantial proportion of cases of HF15,16 and has distinct features compared with heart failure with reduced ejection fraction (HF-REF).16 The prognostic role of hyponatraemia has not been well investigated in HF-PEF. Despite an increasing awareness of the prognostic role of hyponatraemia in HF, treatment strategies remain elusive and, in recent clinical trials, vasopressin receptor antagonists did not reduce mortality.en_NZ
dc.language.isoenen_NZ
dc.subjectheart failureen_NZ
dc.subjectsodiumen_NZ
dc.subjectprognosisen_NZ
dc.subjectmeta-analysisen_NZ
dc.titleRelationship of serum sodium concentration to mortality in a wide spectrum of heart failure patients with preserved and with reduced ejection fraction: an individual patient data meta-analysisen_NZ
dc.title.alternativeMeta-Analysis Global Group in Chronic heart failure (MAGGIC)en_NZ
dc.typeJournal Articleen_NZ
dc.rights.holderEuropean Journal of Heart Failureen_NZ
dc.subject.marsden110201 Cardiology (incl. Cardiovascular Diseases)en_NZ
dc.identifier.bibliographicCitationRusinaru, D., Tribouilloy, C., Berry, C., Richards, A. M., Whalley, G. A., Earle, N., ... & Doughty, R. N. (2012). Relationship of serum sodium concentration to mortality in a wide spectrum of heart failure patients with preserved and with reduced ejection fraction: an individual patient data meta-analysis† Meta-Analysis Global Group in Chronic heart failure (MAGGIC). European journal of heart failure, 14(10), 1139-1146.en_NZ
unitec.institutionUnitec Institute of Technologyen_NZ
unitec.peerreviewedyesen_NZ
dc.contributor.affiliationUnitec Institute of Technologyen_NZ
dc.contributor.affiliationAmiens University Hospital (France)en_NZ
dc.contributor.affiliationWestern Infirmary of Glasgow (Scotland)en_NZ
dc.contributor.affiliationUniversity of Otagoen_NZ
dc.contributor.affiliationUniversity of Aucklanden_NZ
dc.contributor.affiliationUniversity of Milanen_NZ
dc.contributor.affiliationJ.F. Cabral Cardiology Institute (Corrientes, Argentina)en_NZ
dc.contributor.affiliationHospital Pitié-Salpetrière (Paris, France)en_NZ
unitec.identifier.roms54219
unitec.institution.studyareaHealth Sciences


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